Table 2.
Comparison of donor and recipient characteristics among kidneys from living or deceased donors and with optimal or suboptimal histology at CUMC, 2005–2009 (n=975)
| Characteristic | Total | Donor Type | P Value | Donor Histology | P Value | ||
|---|---|---|---|---|---|---|---|
| Deceased | Living | Suboptimal | Optimal | ||||
| N (%) | 975 (100.0) | 548 (56.2) | 427 (43.8) | 414 (42.5) | 561 (57.5) | ||
| Donor characteristics | |||||||
| Age, yr | 42.0±15.9 | 40.8±18.3 | 43.4±11.8 | <0.01 | 50.4±11.4 | 35.7±15.8 | <0.001 |
| Female | 46.4 | 39.6 | 55.0 | <0.001 | 50.7 | 43.1 | 0.02 |
| Black | 15.0 | 18.4 | 10.5 | 0.001 | 16.9 | 13.5 | 0.15 |
| Final creatininea, mg/dl | 1.23±0.91 | 1.52±1.12 | 0.88±0.19 | <0.001 | 1.30±0.83 | 1.19±0.96 | 0.09 |
| BMI≥30 kg/m2 | 25.9 | 30.8 | 19.4 | <0.001 | 33.7 | 20.1 | <0.001 |
| Hypertension | 22.8 | 38.7 | 2.3 | <0.001 | 40.8 | 9.4 | <0.001 |
| Diabetes | 5.0 | 8.9 | 0.0 | <0.001 | 9.1 | 2.0 | <0.001 |
| ECDb | 27.7 | 27.7 | NA | NA | 48.9 | 7.2 | <0.001 |
| KDRI | 1.45±0.43 | 1.45±0.43 | NA | NA | 1.65±0.40 | 1.25±0.35 | <0.001 |
| Recipient characteristics | |||||||
| Age at transplant, yr | 50.8±14.6 | 53.4±13.8 | 47.5±15.0 | <0.001 | 53.2±14.5 | 49.0±14.5 | <0.001 |
| Female | 39.5 | 37.6 | 41.9 | 0.17 | 37.2 | 41.2 | 0.21 |
| Black | 17.1 | 22.7 | 9.8 | <0.001 | 18.7 | 15.9 | 0.25 |
| BMI≥30 kg/m2 | 24.3 | 25.9 | 22.2 | 0.17 | 26.3 | 22.9 | 0.22 |
| Hypertension | 86.1 | 86.5 | 85.5 | 0.67 | 88.2 | 84.5 | 0.10 |
| Diabetes | 30.9 | 35.1 | 25.5 | 0.002 | 34.7 | 28.1 | 0.03 |
| Transplant characteristics | |||||||
| HLA mismatches, no. | 4.0±1.6 | 4.5±1.2 | 3.3±1.7 | <0.001 | 4.1±1.5 | 3.8±1.6 | 0.002 |
| CIT, hb | 30.9±10.6 | 30.9±10.6 | NA | NA | 32.3±9.5 | 29.6±11.5 | 0.004 |
| Previous kidney transplant | 19.3 | 23.2 | 14.3 | 0.001 | 17.1 | 20.9 | 0.15 |
| Biopsy findings | |||||||
| Number of glomeruli | 20.0±12.2 | 20.9±13.2 | 18.9±10.6 | 0.01 | 18.5±10.8 | 21.1±13.0 | <0.001 |
| Glomeruli sclerosed, % | 7.4±10.6 | 9.2±12.4 | 5.1±7.1 | <0.001 | 14.8±12.6 | 1.9±3.0 | <0.001 |
| ATI presence | 30.8 | 46.7 | 10.3 | <0.001 | 37.2 | 26.0 | <0.001 |
| Vascular disease moderate/severe | 28.8 | 35.2 | 20.6 | <0.001 | 67.9 | 0.0 | <0.001 |
| IFTA with ≥5% presence | 10.5 | 15.7 | 3.7 | <0.001 | 23.9 | 0.5 | <0.001 |
| Transplant outcomes | |||||||
| Median follow-up, mo (IQR) | 79.9 (39.1) | 77.1 (57.1) | 84.8 (33.4) | <0.001 | 75.7 (25.4) | 83.1 (34.9) | <0.001 |
| Graft status | |||||||
| Functioning, % | 67.1 | 57.3 | 79.3 | <0.001 | 60.3 | 72.0 | <0.001 |
| Dead, % | 11.2 | 14.1 | 7.5 | 14.2 | 9.0 | ||
| Fail, % | 21.8 | 28.6 | 13.2 | 25.5 | 19.0 | ||
| 5-yr graft survival, % | 83.8 | 77.6 | 91.4 | <0.001 | 79.7 | 86.7 | 0.004 |
| DGF | 25.0 | 40.7 | 4.9 | <0.001 | 32.6 | 19.4 | <0.001 |
| Most recent creatininec, mg/dl | 1.61±0.86 | 1.70±0.94 | 1.51±0.61 | 0.003 | 1.55±0.58 | 1.53±0.85 | 0.78 |
Continuous variables are shown as mean ± standard deviation; categorical variables are reported as column percentages; median follow up is reported as median (interquartile range). ECD, expanded criteria donor; KDRI, kidney donor risk index; HLA, histocompatibility leukocyte antigen; CIT, cold ischemia time; IQR, interquartile range; DGF, delayed graft function.
a
Most recent creatinine before donation for living donors or terminal creatinine for deceased donors.
b
Represented for deceased donor transplants only (n=548).
c
For functioning allografts only.