Fig. 2.

Impact of NAC on systemic platelet and coagulation changes induced by early diabetes: Mice were injected with vehicle (Veh) or streptozotocin (STZ) to induce diabetes. A third group of mice was injected with STZ, and 3 weeks later started on NAC drinking water. 5 wks after injections, blood was drawn for flow cytometry to measure (A) the % of leukocytes and leukocyte subsets forming aggregates with platelets, and (B) CD41 (platelet marker) expression on the aggregates. One week later, at 6 wks post-injection, (C-E) blood was drawn to measure circulating plasma levels of PAI-1, tPA and the ratio of tPA/PAI-1, and (F) tail bleed time was determined. * P < 0.05 vs. Veh; # P < 0.05 vs. STZ.