Figure 5. c-Met inhibitors suppressed viability of ALDH1^high cells derived from Basal-like type of breast cancer cells lines.

A. c-Met and Phosphorylated c-Met (p-Met) expression in ALDH1^high or ALDH1^low cells from MDA-MB157 were analyzed by Immunoblot. β-actin was used as an internal control. B.-C. Cell viability based on formation of formazon product as assessed by the WST-1 assay after 3 days of treatment with c-Met inhibitors, Crizotinib, Foretinib, PHA-665752, and Tivantinib (0.03, 0.1, 0.3, 1, 3 and 10 μM) in ALDH1^high cells derived from MDA-MB157 (B) and MDA-MB468 (C). Numerical values of test groups are shown with respect to 0.02% DMSO treated group. D. In vitro IC₅₀ values of c-Met inhibitors in ALDH1^high cells derived from MDA-MB 157 and MDA-MB 468. All data is represented as the mean± S.D. from three independent experiments.