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. 2017 Jul;8(7-8):628–639. doi: 10.18632/genesandcancer.148

Table 2. List of c-Met inhibitors.

Compound name Action mechanism Targets Reference
NVP-BVU972 ATP competitive Met inhibitor c-Met 43
Tivantinib ATP non-competitive Met inhibitor c-Met 41,42
BMS777607 ATP competitive Met inhibitor c-Met, RON, Axl, TYRO3 and MER 44
AMG-208 ATP competitive Met inhibitor c-Met and RON 45
Cabozantinib ATP competitive Met inhibitor c-Met, VEGFR, RETKIT, FLT3 and TIE2 46
Foretinib ATP competitive Met inhibitor c-Met, VEGFR, AXL, PDGFR, KIT, FLT3 and TIE2 47,48
PF-04217903 ATP competitive Met inhibitor c-Met 49,50
Crizotinib ATP competitive Met inhibitor c-Met and ALK 51,52
PHA-665752 ATP competitive Met inhibitor c-Met, RON, FLK1 and c-Abl 53,54