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. 2017 Jul;8(7-8):640–649. doi: 10.18632/genesandcancer.151

Figure 1. Bioinformatic analyses of PJA1, PJA2 and Smad3 genetic alterations in brain tumors from the databases of The Cancer Genome Atlas.

Figure 1

A. PJA1 and PJA2 RNA expressions shown across 29 cancer types in TCGA databases. RNA expression is shown to be relatively higher in gliomas and glioblastoma multiforme. B. Cancer histogram analysis of genetic alterations of PJA1 and PJA2 in 36 cancer types in TCGA databases. C. Analyses of PJA1, PJA2, and Smad3 expression in the TCGA merged cohort of LGG and GBM dataset TCGA Brain Lower Grade Glioma (LGG) dataset (n = 794). D. Analyses of PJA1, PJA2, and Smad3 genetic alterations in the TCGA LGG dataset (n = 530). Genetic alterations of PJA1 frequently co-occur with Smad3 alterations (p = 0.001) whereas PJA2 alterations are mutually exclusive with Smad3 alterations (p = 0.029). E. Association of PJA1 with Smad3 and Sptbn1 was examined by co-immunoprecipitation with anti-PJA or anti-SPTBN1 in cells transfected with indicated plasmids and the binding of PJA1 with Smad3 and SPTBN1 was determined by anti-V5.