Skip to main content
. 2017 Jul;8(7-8):640–649. doi: 10.18632/genesandcancer.151

Figure 4. PJA1 defects lead to increased cell apoptosis.

Figure 4

A. Apoptotic response to Cisplatin of the Huh7 cells that express a RING domain-deleted PJA1 mutant. The expression of the inactive PJA1 mutant (ΔRING mut) causes more than a three-fold increase in the percentage of apoptotic cells. B. Apoptotic response of HepG2 cells with reduced PJA1 expression after treatment with Sorafenib. PJA1 knockdown demonstrated that Caspase3 and PARP cleavage were significantly elevated compared to control with a dose-dependent pattern. C. The percentage of apoptotic cells is consequently higher in PJA1 knockdown and Sorafenib treatment. D. Negative Pearson's correlation between PJA1 and apoptotic genes in TCGA LGG dataset.