Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 28;7:12362. doi: 10.1038/s41598-017-10267-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

CCR4 promotes HCC cells metastasis in vitro and in vivo. (A and B) Wound-healing assay shows a significant decrease or increase in healing rate of the scramble wound in BEL-7405/shCCR4 and HepG2/CCR4 respectively. (C) Silencing CCR4 in BEL-7405 cells could reduce the migrated cells through transwell assay. (D) Overexpress CCR4 in HepG2 cells could significantly increase the migrated cells through transwell assay. (E) Typical image of the effect on lung metastases of HCC cells via tail vein injection. The arrows in the upper panel indicate lung metastasis tumors. Representative images of ¹⁸F-FLT micro-PET/CT images of mice are shown at the middle panel, arrow indicates ¹⁸F-FLT uptake positivity in thoracic metastatic lesions. While the pathological image showed in the lower panel, arrow indicate metastatic tumors. *p < 0.05, **p < 0.03, ***p < 0.01. Data represent the mean ± SD and are representive of three independent experiments.