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. 2017 Sep 28;8:713. doi: 10.1038/s41467-017-00747-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MRAP2 potentiates the ghrelin-stimulated calcium response in AGRP neurons. (a–c) Two-photon images of the ARC of a AGRP^CRE mouse injected with viruses coding for Cre-dependent tdTomato and GCamp6. d Representative traces of GCamp6 fluorescence intensity over time in AGRP neurons from AGRP^CRE/MRAP2^+/+ (blue) and AGRP^CRE/MRAP2^FL/FL (red) mice. e Quantification of ghrelin-stimulated calcium responses in AGRP neurons from AGRP^CRE/MRAP2^+/+ mice (n = 5 mice/268 neurons) and AGRP^CRE/MRAP2^Fl/Fl mice (n = 7 mice/415 neurons). Error bars are SEM. ***p < 0.001