Fig. 7.

MRAP2 is necessary for ghrelin to induce food intake. a, b Food intake in satiated male WT (a) and Mrap2 KO (b) mice after ICV injection of saline or 13.25 µg ghrelin (n = 6). c, d Food intake in satiated female WT (c) and Mrap2 KO (d) mice after ICV injection of saline or 13.25 µg ghrelin (n = 6). e, f Food intake in satiated male WT (e) and Mrap2 KO (f) mice after ICV injection of saline or 1 or 5 μg of the CB1R agonist ACPA (n = 5/group). g, h Food intake in satiated female WT (g) and Mrap2 KO (h) mice after ICV injection of saline or 1 or 5 μg of the CB1R agonist ACPA (n = 5/group). Error bars are SEM. **p < 0.01, ***p < 0.001