Fig. 3.

The WHHERE complex controls somite bilateral symmetry. a–d RARE-LacZ expression in wild-type a, Rere ^om/om b, Hdac1 ^−/− c and Wdr5 ^fl/+ ; T-Cre d embryos at E8.75-E9.0 (dorsal views). e–h In situ hybridization showing somites labeled with Uncx4.1 in wild-type e, Rere ^om/om f, Hdac1 ^–/– g and Wdr5 ^fl/+ ;T-Cre h embryos at E8.75-E9.0 (dorsal views). i–k Graphs representing the number of 7- somite to 15-somite stage embryos with left-sided (orange), symmetric (blue) or right-sided (green) delay in somite formation: Rere ^om/om i, Hdac1 ^–/– j and Rere ^om/om ;Wdr5 ^fl/+ ;T-Cre k. l–o In situ hybridization for Uncx4.1 in wild-type l, Wdr5 ^fl/+ ;T-Cre m, Rere ^om/om ;Wdr5 ^+/+ n and Rere ^om/om ;Wdr5 ^fl/+ ;T-Cre o embryos at E8.75-E9.0 (dorsal views). For each genotype at least 5–10 embryos were analyzed. Bar = 100 microns