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. Author manuscript; available in PMC: 2017 Dec 21.
Published in final edited form as: Mucosal Immunol. 2017 Mar 29;11(1):144–157. doi: 10.1038/mi.2017.20

Figure 7. Effects of helminth-altered microbiota on Citrobacter infection are mediated by increased Tregs.

Figure 7

a: MLN cells collected from mice colonized with Cont-F and Hp-F with and without C. rodentium-infection and were cultured with surface-bound anti-CD3 mAb. Culture supernatants were collected 48 h later for cytokine determination (ELISA). The data shows that colonization of mice with Hp-F did not alter IFN-γ, IL-4 or IL-17 response, and it drives IL-10 response during C. rodentium infection. b: FACS data shows that colonization of mice with Hp-F induces a significant expansion of CD4+CD25+ T cells in MLN during C. rodentium infection. c: FACS data shows that colonization of mice with Hp-F induces a significant expansion of CD4+Foxp3+, CD4+IL-10+, Foxp3+IL-10+ T cells in MLN during C. rodentium infection. The data shown are the mean ± the SEM (n = 3–5 mice/group) from one of three experiments performed showing similar results. *p < 0.05, **p < 0.01, *** p < 0.005.