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. 2017 Jun 21;8(40):66815–66832. doi: 10.18632/oncotarget.18609

Figure 7. Deregulated gene regulatory network in NK-cell leukemia.

Figure 7

This figure summarizes the results obtained in this study. NKL homeobox gene MSX1 represents a TS in NK-cell malignancies, mediates NK-cell differentiation and inhibits T-cell differentiation as described previously [35]. Deletions at 4p16 which might target the MSX1 locus have been described in NK-cell leukemia patients [11, 13]. Aberrantly expressed upstream factors involved in MSX1 deregulation include IL7R, AUTS2, IRF4, MIR155HG and PRDM1. Deregulated MIR17HG has been described to suppress apoptosis in T-cells [23]. Overexpressed genes are indicated in red, downregulated genes in green.