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DAB2IP blocks the binding of DNMT1 and HDAC2 to miR-138 promoter region. This blocking inhibits the methylation of miR-138 promoter, and increased miR-138 expression leads the degradation of ABCA13 and EZH2 which are involved in CSC development. In advanced RCC, loss of DAB2IP allow to the binding of DNMT1 to miR-138 promoter and suppress miR-138.
