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. 2017 May 10;8(40):66987–67000. doi: 10.18632/oncotarget.17791

Figure 2. The effects of AR overexpression or knockdown on AKT/mTOR signaling.

Figure 2

(A) Overexpression of AR enhanced whereas knockdown of AR suppressed the proteins expression of AKT/mTOR pathway. (B) Knockdown of AR prevented EGF-stimulated up-regulation of AKT1 and AKT2 (n = 3). (C) Stabilization of Akt1/Akt2 by AR overexpression in 34 wk old male TG1/FVB and TG2/FVB mice (n = 4). (D) Overexpression of AR stabilized AKT1/2 whereas knockdown of AR destabilized AKT1/2. (E) Overexpression of AR suppressed AKT1 ubiquitination whereas knockdown of AR promoted AKT1 ubiquitination.