Table 4. The associations of 14 SNPs with childhood obesity and their correlations with five CpG methylations of HIF3A gene.

Genetic association with childhood obesity							The association of methylation quantitations with 14 SNPs
							cg27146050		cg46801562		cg22891070		cg16672562		cg46801675
SNP	BP	A1	GL	NO	OR	P	beta	P	beta	P	beta	P	beta	P	beta	P
rs3826795	46800433	G	intron	688	1.00	0.98	0.39	0.07	−0.63	0.09	0.77	0.05	0.62	0.10	0.42	0.14
rs4802306	46808371	T	intron	692	1.09	0.64	−0.59	0.02	0.21	0.64	−0.77	0.10	−0.46	0.31	−0.22	0.52
rs2311054	46811984	A	exon(syn)	692	0.90	0.60	0.63	0.02	−0.20	0.65	0.40	0.40	−0.24	0.60	−0.23	0.51
rs757638	46812126	A	intron	692	1.01	0.96	0.60	0.02	−0.13	0.77	0.32	0.50	−0.22	0.64	−0.21	0.54
rs759299	46812336	A	intron	692	0.95	0.79	−0.42	0.09	0.27	0.54	−0.20	0.66	0.42	0.33	0.43	0.19
rs61750957	46812451	T	exon(mis)	692	2.31	0.01	−0.35	0.46	0.45	0.58	1.14	0.19	0.97	0.24	0.75	0.23
rs79263603	46814003	G	intron	692	0.97	0.86	−0.06	0.79	0.20	0.63	0.13	0.78	−0.11	0.80	−0.20	0.53
rs8101216	46815297	T	intron	692	0.79	0.32	0.08	0.78	0.24	0.63	−0.41	0.45	−0.39	0.45	0.04	0.91
rs12461322	46815310	A	intron	692	1.00	0.98	−0.06	0.81	0.26	0.54	0.18	0.69	−0.05	0.91	−0.19	0.56
rs8101480	46815499	T	exon(syn)	692	0.83	0.43	0.07	0.82	0.30	0.54	−0.42	0.43	−0.36	0.48	0.05	0.90
rs3764609	46823702	G	exon(mis)	692	1.10	0.58	0.16	0.50	0.11	0.78	0.37	0.38	0.02	0.96	−0.29	0.34
rs3764610	46823751	T	exon(syn)	692	1.00	0.98	0.40	0.10	−0.21	0.60	0.15	0.74	−0.02	0.95	−0.20	0.53
rs77498043	46834320	A	intron	692	0.88	0.74	0.37	0.47	−1.04	0.24	−0.35	0.72	−0.27	0.77	−0.90	0.19
rs11665853	46834683	G	intron	692	1.10	0.58	0.17	0.48	−0.39	0.33	0.30	0.48	0.16	0.69	0.17	0.59

A1: minor allele, GL: gene Location, Sys: synonymous, mis: missense, BP: base positions, OR: odds ratio, NO: number of observations, P values <0.05 are described as bold characters. Test was done by additive effects of allele dosage. Age, sex and BMI were used as covariates for logistic and linear regression analysis.