Figure 3. AKT signaling is involved in the sensitivity of KRAS^MUT/TP53^MUT lung cancer to AZD1775.

Cells were treated with 500 nM AZD1775 for the indicated times. (A) Phosphorylation of AKT was determined by immunoblotting. (B) Phosphorylation of ERK was determined by immunoblotting. MUT, mutant; WT, wild-type.