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. 2017 Jun 28;8(40):67670–67683. doi: 10.18632/oncotarget.18802

Figure 5. Dexamethasone suppresses NF-κB activity in colon cancer.

Figure 5

(A–D) Microarray datasets from CRC patients (GSE39582) and from CRC cell lines showed IκBα significantly correlated with GRα (A and B), and with GRβ (C and D). (E) NF-κB p65immunohistochemistry of colon cancer. (F) RT-PCR. (G) Western blot. (H) LoVo cells were treated with dexamethasone as indicated and NF-κB activity was assayed using EMSA. (I) Western blot. Knockdown of NF-κB p65 increased oxaliplatin induced cleaved caspase 3, an apoptotic marker.