Table 2. Patient characteristics according to different breast cancer subtypes.
| Characteristic | HR+/HER2- | HR+/HER2+ | HR-/HER2+ | HR-/HER2- | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No surgery (%) | Surgery (%) | P value | No surgery (%) | Surgery (%) | P value | No surgery (%) | Surgery (%) | P value | No surgery (%) | Surgery (%) | P value | |
| Age (years) | ||||||||||||
| <35 | 94 (2.4) | 52 (3.0) | < 0.001 | 47 (4.7) | 45 (8.4) | < 0.001 | 21 (4.0) | 26 (8.1) | 0.009 | 27 (3.5) | 24 (4.4) | 0.031 |
| 35-50 | 636 (16.6) | 424 (24.5) | 216 (21.7) | 145 (27.0) | 120 (22.8) | 86 (26.9) | 157 (20.5) | 142 (26.1) | ||||
| >50 | 3107 (81.0) | 1253 (72.5) | 732 (73.6) | 347 (64.6) | 386 (73.2) | 208 (65.0) | 583 (76.0) | 378 (69.5) | ||||
| Race | ||||||||||||
| White | 2977 (78.0) | 1346 (78.1) | 0.373 | 735 (74.5) | 402 (74.9) | 0.373 | 378 (72.1) | 221 (69.5) | 0.231 | 513 (67.0) | 364 (67.0) | 0.863 |
| Black | 562 (14.7) | 237 (13.7) | 180 (18.2) | 89 (16.6) | 98 (18.7) | 56 (17.6) | 206 (26.9) | 142 (26.2) | ||||
| Other | 279 (7.3) | 141 (8.2) | 72 (7.3) | 46 (8.6) | 48 (9.2) | 41 (12.9) | 47 (6.1) | 37 (6.8) | ||||
| Grade | ||||||||||||
| Well differentiated | 354 (12.2) | 169 (10.4) | < 0.001 | 17 (2.1) | 8 (1.6) | < 0.001 | 1 (0.2) | 3 (1.0) | 0.042 | 14 (2.3) | 3 (0.6) | < 0.001 |
| Moderately differentiated | 1547 (53.5) | 733 (45.2) | 339 (42.1) | 162 (32.1) | 123 (29.2) | 67 (22.3) | 136 (22.3) | 62 (12.1) | ||||
| Poorly/undifferentiated | 989 (34.2) | 719 (44.4) | 450 (55.8) | 334 (66.3) | 297 (70.5) | 230 (76.7) | 459 (75.4) | 449 (87.4) | ||||
| Tumor size (cm) | ||||||||||||
| ≤2 | 534 (18.5) | 261 (16.0) | 0.074 | 128 (17.1) | 82 (16.6) | 0.074 | 50 (13.2) | 53 (18.5) | 0.164 | 98 (17.3) | 58 (11.6) | 0.018 |
| >2-5 | 1401 (48.4) | 794 (48.6) | 375 (50.0) | 241 (48.9) | 175 (46.1) | 127 (44.3) | 242 (42.7) | 212 (42.4) | ||||
| >5 | 959 (33.1) | 578 (35.4) | 247 (32.9) | 170 (34.5) | 155 (40.8) | 107 (37.3) | 227 (40.0) | 230 (46.0) | ||||
| Nodal stage | ||||||||||||
| N0 | 948 (28.5) | 290 (17.1) | < 0.001 | 208 (23.4) | 90 (17.2) | < 0.001 | 76 (16.1) | 47 (15.1) | < 0.001 | 133 (19.3) | 101 (19.1) | < 0.001 |
| N1 | 1721 (51.7) | 637 (37.6) | 483 (54.5) | 210 (40.2) | 264 (55.9) | 115 (37.0) | 363 (52.8) | 213 (40.3) | ||||
| N2 | 304 (9.1) | 345 (20.4) | 93 (10.5) | 104 (19.9) | 51 (10.8) | 65 (20.9) | 48 (7.0) | 84 (15.9) | ||||
| N3 | 356 (10.7) | 420 (24.8) | 103 (11.6) | 119 (22.8) | 81 (17.2) | 84 (27.0) | 144 (20.9) | 131 (24.8) | ||||
| Marital status | ||||||||||||
| Unmarried | 2064 (57.1) | 800 (48.8) | < 0.001 | 528 (56.2) | 241 (47.1) | < 0.001 | 274 (55.4) | 140 (47.3) | 0.028 | 426 (58.2) | 278 (53.2) | 0.076 |
| Married | 1551 (42.9) | 838 (51.2) | 412 (43.8) | 271 (52.9) | 221 (44.6) | 156 (52.7) | 306 (41.8) | 245 (46.8) | ||||
HER2, human epidermal growth factor receptor; HR, hormone receptor.