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. 2017 Jul 12;8(40):68153–68164. doi: 10.18632/oncotarget.19249

Figure 2. Histopathological analysisof lung tissues (HE, 200x). Lungs from each experimental group were processed for histological evaluation.

Figure 2

(A) Lung tissue of the control group, (B) the LPS group, and (C) to (E) the Ori-treated groups (10, 20, 40 μg/mL, respectively). The green arrows indicate alveolar macrophages. Effects of Ori on lung W/D ratio (F) and MPO activity;“g” represents tissue weight (G). CG is the control group; LPS is the LPS group; and 10, 20 and 40 represent the Ori-treated groups at 10 mg/kg, 20mg/kg and 40mg/kg of Ori per animal, respectively. The values are shown as the means ± SEM (n=3). (H) Administration of Ori improved survival during ALI. Oridonin (Ori) was administered after establishment of LPS-induced ALI (3 mg/kg). Kaplan–Meier survival curve shows that Ori significantly improved the survival rate during 72 h compared to the LPS group. Data represent the mean ±SEM (n = 15), #p< 0.05, ##p< 0.01 versus CG; *p< 0.05, **p< 0.01 versus LPS.