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. 2017 Aug 4;8(40):68208–68220. doi: 10.18632/oncotarget.19919

Figure 1. Sorafenib protects AML cells from BV6-induced necroptosis.

Figure 1

Figure 1

(A–C) Molm13 and MV4-11 cells were treated for 6 hours (Molm13) or 24 hours (MV4-11) with 3 μM BV6 and 40 μM zVAD.fmk in the presence or absence of indicated concentrations of Sorafenib (A), GSK’872 (B) or Dabrafenib (C). (D) Molm13 and MV4-11 cells were treated for 6 hours (Molm13) or 24 hours (MV4-11) with 3 μM BV6 and 40 μM zVAD.fmk in the presence or absence of 10 μM Sorafenib, 10 μM GSK’872 or 10 μM Dabrafenib. (E) Molm13 and MV4-11 cells were treated with or without 3 μM BV6 and 40 μM zVAD.fmk in the presence or absence of 10 μM Sorafenib for the indicated time points. (A–E) cell death was determined by PI staining and flow cytometry. Mean and SD of at least three experiments performed in triplicate are shown; *P < 0.05; **P < 0.01; ***P < 0.001.