Figure 2. PKM2 overexpression promotes TSCC cell migration and invasion.

(A) Western blot analysis showing the levels of the PKM2, pERK, ERK and EMT marker (E-cad, Vimentin, and Slug) proteins in UM2 cells infected with a lentiviral construct containing the PKM2 cDNA (LV-PKM2) or with the control lentiviral construct (Vector). PKM2 overexpression promoted UM2 cell migration (B) and invasion (C). PKM2 overexpression also resulted in increased UM2 cell proliferation (D), SOD2 expression and activity (E) and H₂O₂ production (F). *P<0.05.