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. 2017 Jul 17;8(40):68252–68262. doi: 10.18632/oncotarget.19291

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Copyright: © 2017 Wang et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Western blot results showing the levels of the PKM2, pERK, ERK and EMT marker (E-cad, Vimentin, and Slug) proteins in UM1 cells transfected with the PKM2 siRNA or control siRNA. PKM2 knockdown inhibited the migration (B) and invasion (C) of UM1 cells. PKM2 knockdown also inhibited UM1 cell proliferation (D), SOD2 expression and activity (E) and H₂O₂ production (F). *P<0.05.