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. 2017 Jul 17;8(40):68252–68262. doi: 10.18632/oncotarget.19291

Figure 5. PKM2 knockdown inhibits TSCC xenograft growth and lung metastasis in vivo.

Figure 5

(A) CAL27 cells stably infected with lentiviral constructs containing control shRNA or PKM2 shRNA were subcutaneously injected into nude mice. Xenografts were measured every 3 days with a calliper, and the resulting growth curves demonstrated that PKM2 knockdown significantly inhibited CAL27 xenograft growth. (B) UM1 cells stably infected with lentiviral constructs containing control shRNA or PKM2 shRNA were injected into the tail vein of nude mice. TSCC metastasis to the lung was assessed 8 weeks after injection. The histopathological analysis of lung metastasis (magnification 400×) and metastatic lung nodules are shown. PKM2 expression in xenografts (A) and lung metastases (B) was analysed using IHC. Scale bar: 50 μm. *P<0.05.