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. 2017 Aug 3;8(40):68707–68720. doi: 10.18632/oncotarget.19844

Figure 1. Treatment with PARP inhibitors protects WT mice against sex- and AAG-dependent MMS-induced retinal degeneration.

Figure 1

(A) Representative H&E-stained images of retinas from WT mice and Parp1−/− mice 7 days after MMS (75 mg/kg) and PARP inhibitor (VEL, Veliparib 10 mg/kg; OLA, Olaparib 50 mg/kg) treatment, as indicated. PARP inhibitors were administered to WT mice 1 hour prior to MMS treatment. Magnification is 200X (scale bar 50 μm); ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; CTR, untreated control mice; ♂, males; ♀, females. (B) Quantification of rows of photoreceptor nuclei in the outer nuclear layer of WT and Parp1−/− mice 7 days after MMS (75 mg/kg) and PARP inhibitors (VEL, Veliparib 10 mg/kg; OLA, Olaparib 50 mg/kg) treatment, as indicated. *, p < 0.05; **, P < 0.01; ♂, males; ♀, females.