Table 2. The differentially expressed inflammation-relative genes in heart tissue of minipigs treated with or without myoblast transplantation post-MI.
| Gene_Symbol | Gene_Title | Fold change (Myo/NC) |
|---|---|---|
| LOC100525766 | serine/threonine-protein kinase PAK 1-like | 0.018209086 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 0.039351824 |
| TLR4 | Toll-like receptor 4 | 0.053853831 |
| LOC100515801 | Uncharacterized protein KIAA1383 homolog | 0.07255373 |
| IL1B | Interleukin 1 beta | 0.154663889 |
| LOC100519703 | proteinase-activated receptor 2-like | 0.185482438 |
| TNF | Tumor necrosis factor | 0.189656668 |
| LBP | lipopolysaccharide binding protein | 0.22179613 |
| LOC100512070 | glucose-6-phosphatase 3-like | 0.251654884 |
| LOC100154770 | radiation-inducible immediate-early gene IEX-1-like | 0.287977899 |
| LOC100525766 | serine/threonine-protein kinase PAK 1-like | 0.293721545 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.29759855 |
| PRL | prolactin | 0.307770743 |
| GATA3 | GATA binding protein 3 | 0.311184563 |
| ADRA1B | adrenoceptor alpha 1B | 0.339089567 |
| RHOB | ras homolog family member B | 0.339561077 |
| PPARGC-1 | peroxisome proliferator activated receptor gamma, coactivator 1 alpha | 0.345113903 |
| IGF1R | insulin-like growth factor 1 receptor | 0.364555886 |
| AMHR2 | anti-Mullerian hormone receptor, type II | 0.369864566 |
| COL3A1 | Collagen, type III, alpha 1 | 0.370578657 |
| LOC100155615 | vasopressin-induced protein, 32kDa | 0.377345245 |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | 0.381822705 |
| SLA-DRB1 | MHC class II histocompatibility antigen SLA-DRB1 | 0.387633403 |
| ACCN2 | acid-sensing (proton-gated) ion channel 1 | 0.391439296 |
| MAPK8 | Mitogen-activated protein kinase 8, JNK1 | 0.396123721 |
| LBP | lipopolysaccharide binding protein | 0.400341256 |
| E2F7 | E2F transcription factor 7 | 0.401168991 |
| LOC100621324 | heat shock-related 70 kDa protein 2-like | 0.411213633 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.416144478 |
| LOC100523833 | fibroblast growth factor 13-like | 0.419831988 |
| BDNF | brain-derived neurotrophic factor | 0.42688193 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.439591227 |
| PLAA | phospholipase A2-activating protein | 0.446603047 |
| TGFB2 | transforming growth factor, beta 2 | 0.461156871 |
| RORA | RAR-related orphan receptor A | 0.46211275 |
| FOXO1 | forkhead box O1 | 0.462757924 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.463425071 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.47786811 |
| GATA3 | GATA binding protein 3 | 0.487248416 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.488153338 |
| APOA2 | apolipoprotein A-II | 0.49103491 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.49244312 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.496903153 |
| HYAL2 | hyaluronoglucosaminidase 2 | 0.498768065 |
| LOC100738351 | microtubule-associated protein tau-like | 0.499859657 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 2.006498392 |
| LOC100515801 | uncharacterized protein KIAA1383 homolog | 2.027618033 |
| HMGB1 | high mobility group box 1 | 2.07995541 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.108144854 |
| CYP2J34 | cytochrome P450, family 2, subfamily J, polypeptide 34 | 2.139775885 |
| DUSP6 | dual specificity phosphatase 6 | 2.205287882 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 2.259628027 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 2.280422277 |
| THBS1 | Thrombospondin 1 | 2.325687086 |
| THBS1 | thrombospondin 1 | 2.356147732 |
| HSPA8 | heat shock 70kDa protein 8 | 2.36804402 |
| DUSP6 | dual specificity phosphatase 6 | 2.421761848 |
| SYK | spleen tyrosine kinase | 2.422838934 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.478801936 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 2.502965317 |
| LOC100514374 | dual specificity protein phosphatase 4-like | 2.606314171 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | 2.609206269 |
| ELK4 | ETS-domain protein (SRF accessory protein 1) | 2.812234501 |
| C3 | complement component 3 | 2.877851202 |
| ADA | adenosine deaminase | 2.901005438 |
| LOC100519703 | Proteinase-activated receptor 2-like | 3.230116054 |
| ACP5 | acid phosphatase 5, tartrate resistant | 3.33994883 |
| IL10 | interleukin 10 | 3.394530387 |
| LOC100518643 | Interleukin-33-like | 3.693850557 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 3.733013174 |
| CPT1C | carnitine palmitoyltransferase 1C | 3.738067187 |
| THBS1 | thrombospondin 1 | 4.004670655 |
| FGFR2 | fibroblast growth factor receptor 2 | 4.566747424 |
| MME | membrane metallo-endopeptidase | 4.625607971 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 5.54041483 |
| CCL21 | chemokine (C-C motif) ligand 21 | 5.607199497 |
| CCL2 | chemokine (C-C motif) ligand 2 | 5.630495932 |
| LPAR2 | lysophosphatidic acid receptor 2 | 6.141604456 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 7.729290554 |
| S100A9 | S100 calcium binding protein A9 | 8.279375777 |
| NTRK3 | Neurotrophic tyrosine kinase, receptor, type 3 | 10.19038462 |
| THBS1 | thrombospondin 1 | 14.95862849 |
Myo: myoblasts; NC, control treatment group.