Table 3. Meta-analysis of the relationships between miR196a2 (rs11614913 C > T) polymorphism and breast cancer risk.
| Group | Included studies | Genotype models | OR (95% CI) | Z | P | Heterogeneity test | |
|---|---|---|---|---|---|---|---|
| Ph | I2 | ||||||
| Total | 12 studies | T vs. C | 0.90 (0.81, 1.00) | 1.97 | 0.049 | 0 | 69.00% |
| TT vs. CC | 0.83 (0.67, 1.02) | 1.76 | 0.079 | 0.001 | 68.00% | ||
| TC vs. CC | 0.92 (0.85, 1.00) | 1.88 | 0.06 | 0.28 | 16.70% | ||
| TT + TC vs. CC | 0.88 (0.78, 1.01) | 1.88 | 0.06 | 0.015 | 53.10% | ||
| TT vs. CC + TC | 0.86 (0.74, 1.00) | 2.01 | 0.044 | 0.008 | 58.00% | ||
| Asian | 6 studies | T vs. C | 0.85 (0.71, 1.02) | 1.75 | 0.08 | 0.001 | 75.50% |
| TT vs. CC | 0.78 (0.54, 1.12) | 1.36 | 0.175 | 0.003 | 74.70% | ||
| TC vs. CC | 0.85 (0.74, 0.99) | 2.17 | 0.03 | 0.135 | 40.60% | ||
| TT + TC vs. CC | 0.81 (0.63, 1.05) | 1.59 | 0.112 | 0.021 | 62.40% | ||
| TT vs. CC + TC | 0.83 (0.67, 1.04) | 1.65 | 0.099 | 0.014 | 67.90% | ||
| Caucasian | 4 studies | T vs. C | 0.91 (0.80, 1.03) | 1.55 | 0.121 | 0.097 | 52.50% |
| TT vs. CC | 0.79 (0.59, 1.08) | 1.49 | 0.136 | 0.041 | 63.70% | ||
| TC vs. CC | 0.95 (0.85, 1.06) | 0.92 | 0.358 | 0.771 | 0.00% | ||
| TT + TC vs. CC | 0.94 (0.85, 1.05) | 1.08 | 0.282 | 0.24 | 28.70% | ||
| TT vs. CC + TC | 0.83 (0.64, 1.08) | 1.38 | 0.167 | 0.063 | 58.80% | ||
| Mix | 2 studies | T vs. C | 1.16 (0.72, 1.86) | 0.62 | 0.538 | 0.042 | 75.90% |
| TT vs. CC | 1.31 (0.53, 3.28) | 0.58 | 0.559 | 0.049 | 74.20% | ||
| TC vs. CC | 1.02 (0.80, 1.29) | 0.15 | 0.877 | 0.196 | 40.10% | ||
| TT + TC vs. CC | 1.23 (0.63, 2.39) | 0.6 | 0.548 | 0.084 | 66.60% | ||
| TT vs. CC + TC | 1.12 (0.65, 1.94) | 0.41 | 0.678 | 0.129 | 56.60% | ||
| Population-based | 6 studies | T vs. C | 0.94 (0.85, 1.04) | 1.21 | 0.228 | 0.126 | 41.90% |
| TT vs. CC | 0.89 (0.74, 1.07) | 1.28 | 0.2 | 0.211 | 31.60% | ||
| TC vs. CC | 0.94 (0.84, 1.04) | 1.22 | 0.224 | 0.476 | 0.00% | ||
| TT + TC vs. CC | 0.91 (0.81, 1.03) | 1.44 | 0.151 | 0.263 | 22.70% | ||
| TT vs. CC + TC | 0.92 (0.81, 1.05) | 1.23 | 0.22 | 0.339 | 11.70% | ||
| Hospital-based | 6 studies | T vs. C | 0.87 (0.72, 1.05) | 1.41 | 0.159 | 0 | 78.90% |
| TT vs. CC | 0.76 (0.51, 1.13) | 1.35 | 0.178 | 0 | 78.30% | ||
| TC vs. CC | 0.90 (0.79, 1.03) | 1.5 | 0.132 | 0.132 | 41.00% | ||
| TT + TC vs. CC | 0.87 (0.68, 1.11) | 1.11 | 0.266 | 0.007 | 68.60% | ||
| TT vs. CC + TC | 0.79 (0.60, 1.02) | 1.79 | 0.073 | 0.007 | 68.60% | ||
| Sample-size < 500 | 4 studies | T vs. C | 1.07 (0.79, 1.45) | 0.43 | 0.667 | 0.058 | 59.90% |
| TT vs. CC | 1.43 (0.81, 2.52) | 1.23 | 0.218 | 0.178 | 42.10% | ||
| TC vs. CC | 0.96 (0.70, 1.31) | 0.25 | 0.801 | 0.149 | 43.80% | ||
| TT + TC vs. CC | 1.07 (0.66, 1.76) | 0.28 | 0.778 | 0.066 | 58.30% | ||
| TT vs. CC + TC | 1.21 (0.92, 1.59) | 1.36 | 0.173 | 0.502 | 0.00% | ||
| Sample size ≥ 500 | 8 studies | T vs. C | 0.87 (0.78, 0.96) | 2.74 | 0.006 | 0.002 | 70.00% |
| TT vs. CC | 0.75 (0.61, 0.93) | 2.66 | 0.008 | 0.003 | 68.00% | ||
| TC vs. CC | 0.92 (0.85, 1.00) | 1.88 | 0.06 | 0.349 | 10.50% | ||
| TT + TC vs. CC | 0.86 (0.76, 0.98) | 2.22 | 0.026 | 0.029 | 55.20% | ||
| TT vs. CC + TC | 0.80 (0.69, 0.93) | 2.94 | 0.003 | 0.03 | 54.90% | ||
Notes: OR = Odds ratios; 95% CI = 95% confidence intervals.