Table 4. Meta-analysis of the relationships between miR499 (rs3746444 A > G) polymorphism and breast cancer risk.
| Group | Included studies | Genotype models | OR (95% CI) | Z | P | Heterogeneity test | |
|---|---|---|---|---|---|---|---|
| Ph | I2 | ||||||
| Total | 7 studies | G vs. A | 1.15 (1.07, 1.24) | 3.76 | 0 | 0.155 | 35.90% |
| GG vs. AA | 1.32 (1.10, 1.58) | 2.99 | 0.003 | 0.239 | 24.80% | ||
| GA vs. AA | 1.13 (1.03, 1.24) | 2.48 | 0.013 | 0.078 | 47.20% | ||
| GG + GA vs. AA | 1.16 (1.06, 1.27) | 3.23 | 0.001 | 0.151 | 36.40% | ||
| GG vs. AA + GA | 1.27 (1.06, 1.51) | 2.65 | 0.008 | 0.071 | 48.30% | ||
| Asian | 4 studies | G vs. A | 1.26 (1.14, 1.40) | 4.52 | 0 | 0.567 | 0.00% |
| GG vs. AA | 1.60 (1.26, 2.04) | 3.84 | 0 | 0.795 | 0.00% | ||
| GA vs. AA | 1.17 (1.02, 1.33) | 2.31 | 0.021 | 0.321 | 14.20% | ||
| GG + GA vs. AA | 1.25 (1.10, 1.41) | 3.46 | 0.001 | 0.492 | 0.00% | ||
| GG vs. AA + GA | 1.60 (1.27, 2.02) | 4.01 | 0 | 0.77 | 0.00% | ||
| Caucasian | 3 studies | G vs. A | 1.04 (0.93, 1.15) | 0.69 | 0.493 | 0.794 | 0.00% |
| GG vs. AA | 1.01 (0.76, 1.34) | 0.06 | 0.955 | 0.605 | 0.00% | ||
| GA vs. AA | 1.19 (0.88, 1.60) | 1.1 | 0.271 | 0.026 | 72.50% | ||
| GG + GA vs. AA | 1.14 (0.89, 1.39) | 0.96 | 0.335 | 0.113 | 54.20% | ||
| GG vs. AA + GA | 0.94 (0.71, 1.24) | 0.45 | 0.65 | 0.194 | 39.10% | ||
| Population-based | 3 studies | G vs. A | 1.10 (1.00, 1.20) | 1.96 | 0.05 | 0.114 | 53.90% |
| GG vs. AA | 1.19 (0.93, 1.53) | 1.4 | 0.162 | 0.124 | 52.00% | ||
| GA vs. AA | 1.09 (0.97, 1.22) | 1.48 | 0.139 | 0.327 | 10.60% | ||
| GG + GA vs. AA | 1.11 (0.99, 1.23) | 1.81 | 0.07 | 0.229 | 32.10% | ||
| GG vs. AA + GA | 1.16 (0.90, 1.48) | 1.16 | 0.247 | 0.116 | 53.50% | ||
| Hospital-based | 4 studies | G vs. A | 1.25 (1.11, 1.41) | 3.63 | 0 | 0.554 | 0.00% |
| GG vs. AA | 1.48 (1.13, 1.93) | 2.87 | 0.004 | 0.474 | 0.00% | ||
| GA vs. AA | 1.21 (1.02, 1.43) | 2.22 | 0.027 | 0.042 | 63.30% | ||
| GG + GA vs. AA | 1.28 (1.09, 1.49) | 3.03 | 0.002 | 0.223 | 31.50% | ||
| GG vs. AA + GA | 1.39 (1.08, 1.79) | 2.6 | 0.009 | 0.104 | 51.30% | ||
| Sample-size < 500 | 1 study | G vs. A | 1.19 (0.79, 1.78) | 0.83 | 0.408 | NA | NA |
| GG vs. AA | 0.80 (0.30, 2.12) | 0.45 | 0.654 | NA | NA | ||
| GA vs. AA | 2.33 (1.26, 4.28) | 2.71 | 0.007 | NA | NA | ||
| GG + GA vs. AA | 1.91 (1.07, 3.41) | 2.18 | 0.029 | NA | NA | ||
| GG vs. AA + GA | 0.49 (0.20, 1.22) | 1.53 | 0.126 | NA | NA | ||
| Sample size ≥ 500 | 6 studies | G vs. A | 1.15 (1.07, 1.24) | 3.67 | 0 | 0.097 | 46.40% |
| GG vs. AA | 1.34 (1.12, 1.62) | 3.13 | 0.002 | 0.226 | 27.90% | ||
| GA vs. AA | 1.11 (1.01, 1.22) | 2.07 | 0.039 | 0.326 | 13.90% | ||
| GG + GA vs. AA | 1.15 (1.05, 1.25) | 2.93 | 0.003 | 0.258 | 23.50% | ||
| GG vs. AA + GA | 1.32 (1.10, 1.58) | 3.03 | 0.002 | 0.202 | 31.10% | ||
Notes: OR = Odds ratios; 95% CI = 95% confidence intervals; NA = Not available.