Table 2. Summary of meta-analysis results.
Factors | No. of studies | No. of patients | Effects model | HR(95% CL) | P | Heterogeneity | |
---|---|---|---|---|---|---|---|
I2(%) | Ph | ||||||
Overall survival (OS) | |||||||
Overall | 16 | 4910 | Random | 1.50 (1.27-1.77) | < 0.001 | 80.2% | < 0.001 |
Ethnicity: | |||||||
Caucasian | 5 | 1269 | Random | 1.36 (0.99-1.87) | 0.058 | 72.0% | 0.006 |
Asian | 11 | 3641 | Random | 1.69 (1.31-2.21) | < 0.001 | 83.5% | < 0.001 |
Sample size: | |||||||
<200 | 8 | 1605 | Random | 2.29 (1.49-3.52) | < 0.001 | 69.4% | 0.002 |
≥200 | 8 | 3305 | Random | 1.23 (1.07-1.41) | 0.002 | 69.6% | 0.002 |
Histologic types: | |||||||
Epithelial | 8 | 2622 | Random | 1.28 (1.09-1.50) | 0.003 | 71.8% | 0.001 |
Mixed | 8 | 2288 | Random | 1.93 (1.35-2.77) | < 0.001 | 77.9% | < 0.001 |
Cut-off value: | |||||||
<3.4 | 7 | 2600 | Random | 1.30 (1.05-1.61) | 0.014 | 60.9% | 0.018 |
≥3.4 | 9 | 2310 | Random | 1.89 (1.35-2.65) | < 0.001 | 86.2% | < 0.001 |
NOS score: | |||||||
<7 | 7 | 1775 | Random | 1.49 (1.24-1.68) | 0.005 | 70.7% | 0.002 |
≥7 | 9 | 3135 | Random | 1.66 (1.24-2.22) | 0.001 | 84.5% | < 0.001 |
Progression free survival (PFS) | |||||||
Overall | 12 | 3884 | Random | 1.53 (1.28-1.84) | < 0.001 | 85.2% | < 0.001 |
Ethnicity: | |||||||
Caucasian | 3 | 515 | Fixed | 1.25 (1.10-1.42) | 0.001 | 27.5% | 0.252 |
Asian | 9 | 3369 | Random | 1.59 (1.25-1.84) | < 0.001 | 88.0% | < 0.001 |
Sample size: | |||||||
<200 | 6 | 1333 | Random | 1.83 (1.24-2.69) | 0.002 | 73.1% | < 0.001 |
≥200 | 6 | 2551 | Random | 1.35 (1.13-1.62) | 0.001 | 83.0% | < 0.001 |
Histology type: | |||||||
Epithelial | 6 | 2350 | Random | 1.32 (1.09-1.59) | 0.005 | 83.5% | < 0.001 |
Non-epithelial | 6 | 1534 | Random | 2.07 (1.39-3.01) | < 0.001 | 75.4% | 0.001 |
Cut-off value: | |||||||
<3.4 | 6 | 2408 | Fixed | 1.28 (1.17-1.40) | < 0.001 | 29.9% | 0.211 |
≥3.4 | 6 | 1476 | Random | 2.09 (1.30-3.37) | < 0.001 | 90.5% | < 0.001 |
Analysis method: | |||||||
Univariate | 2 | 377 | Fixed | 1.09 (1.06-1.12) | < 0.001 | 0.0% | 0.768 |
Multivariate | 10 | 3507 | Random | 1.43 (1.19-1.71) | < 0.001 | 84.4% | < 0.001 |
NOS score: | |||||||
<7 | 6 | 1256 | Random | 1.57 (1.15-2.15) | 0.005 | 68.4% | 0.007 |
≥7 | 6 | 2628 | Random | 1.54 (1.18-2.01) | 0.001 | 88.8% | < 0.001 |
P denotes P value for statistical significance based on Z test; Ph denotes P value for heterogeneity based on Q test. HR hazard ratio; CI confidence interval.