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. 2017 Aug 4;8(40):69139–69161. doi: 10.18632/oncotarget.19932

Figure 3. Interactions between STAT3 and other proteins.

Figure 3

This figure is generated using the website STITCH (http://stitch.embl.de/). The proteins were submitted to the human database. The interactions provided by the database are based on the eight aspects: known interactions encompassing results from curated databases, experimentally determined and predicted interactions gene neighborhood, gene fusions, and gene co-occurrence, textmining, co-expression, and protein homology. Only the proteins relevant to tumor angiogenesis and directly interplaying with STAT3 are shown. (ARNT, aryl hydrocarbon receptor nuclear translocator; CBL, Cbl proto-oncogene, E3 ubiquitin protein ligase; CISH, cytokine inducible SH2-containing protein; C-JUN, jun proto-oncogene; DNMT1, DNA (cytosine-5)-methyltransferase 1; EGFR, epidermal growth factor receptor; EP300, E1A binding protein p300; GRB2, growth factor receptor-bound protein 2; HIF-1α, hypoxia-inducible factor 1 subunit α; HDAC1, histone deacetylase 1; JAK, Janus kinase; MAPK1/3, mitogen-activated protein kinase 1/3; MAP2K1, mitogen-activated protein kinase kinase 1; NDUFA13, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 13; NIK, NF-κB-inducing kinase; NR4A1, nerve growth factor-induced gene B; PI3K, phosphatidylinositol 3-kinase; PIAS3, protein inhibitor of activated STAT3; RAC1, Ras-related C3 botulinum toxin substrate 1; RBBP4/7, retinoblastoma binding protein 4/7; RELA, v-relreticuloendotheliosis viral oncogene homolog A; SIN3A, SIN3 transcription regulator homolog A; SOCS, suppressors of cytokinesignaling; SOS1, son of sevenless homolog 1; STAT1/3/5A/5B, signal transducers and activators of transcription 1/3/5A/5B; SP1, specificity protein 1; SRC, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog).