| Natural |
|
|
|
| Scoparone |
VSMC |
Blocks the transportation of STAT3 from the cytosol to the nucleus |
[169] |
| Indoxyl sulfate |
Mouse EPCs/ human EPCs |
Unclear |
[182] |
| adiponectin |
Human VSM and VECs |
Induces SOCS to inhibit STAT3 |
[184] |
| melatonin |
HepG2/HeLa/ HUVECs |
Unclear |
[186] |
| Tanshinone I |
Vascular endothelial cells/ tumor |
Inhibits STAT3 705 Tyr-phosphorylation |
[85] |
| Indirubin |
Human endothelial cells/ tumor |
Inhibits VEGFR/JAK2/ STAT3 phosphorylation |
[178] |
| Wogonin |
Tumor/ HUVECs |
Inhibits STAT3 705 Tyr-phosphorylation and promotes dephosphorylation |
[172] |
| Astaxanthin |
Tumor |
Inhibit STAT3 phosphorylation |
[170] |
| GYY4137 |
Human hepatocellular carcinoma (HCC) |
Inhibits JAK2/STAT3 |
[195] |
| Icaritin |
Renal cell carcinoma |
Inhibits IL-6-induced STAT3 705 Tyr-phosphorylation |
[191] |
| Butein |
Human Multiple Myeloma/ tumor |
Induces SHP-1 to dephosphorylate JAK2 and STAT3 |
[199] |
| resveratrol |
Tumor |
Induces GRIM19 to inhibit STAT3 |
[203] |
| Acacetin |
HUVECs/ tumor |
Inhibits STAT3 705 Tyr-phosphorylation |
[187] |
| α -Solanine |
Tumor |
Unclear |
[205] |
| JSI-124 (Cucurbitacin I) |
Tumor |
Unclear |
[183] |
| Synthetic |
|
|
|
| TEL03 |
Tumor |
Inhibits STAT3 phosphorylation by interacting with SH2 domain |
[190] |
| LCB03-0110 |
Human endothelial cells/ tumor |
Targets VEGFR-2 kinase activity by binding to the ATP-binding site |
[177] |
| P3971 |
Tumor |
Unclear |
[185] |
