Figure 2. Hypothesis: LncRNAs associated the patients’ response to anti-PD-1 or anti-PDL-1 treatment.

(A) LncRNAs could be precursors of miRNAs. P53 regulated PDL-1 via miR-34, and miR-34 enhanced T cell activation via targeting diacylglycerol kinase ζ. (B) LncRNAs could act as ceRNAs to alter the distribution of miRNA molecules on their targets.