Table 4. Summary of prospective studies of sentinel node biopsy after neoadjuvant chemotherapy in cN+ axilla.
ACOSOG Z1071 [73] | SENTINA [74] | SN FNAC [75] | |
---|---|---|---|
Design | Single arm | 4 Arms | Single arm |
No. of patients | 756 | Arm C (592) | 153 |
Patient population | T0-4, N1-2, M0 | N1-2, M0 | T0-3, N1-2 |
SLN identification rate (%) | 92.9 | 80.1 | 87.6 |
False negative rate (%) | 12.6 | 14.2 | 9.6 |
2 SLNs | 21.1 | 18.5 | 4.9 ( ≥ 2 SLNs) |
3 SLNs | 9.1 | 7.3 | - |
Dual tracer technique | 10.8 | 8.6 | 5.2 |
Inclusion of ypN0(i+) | 8.7 | - | 8.4 |
SLN=sentinel lymph node.