Table 5. pCR rate according to the intrinsic biological subtypes from CNB in NAC patients.
Subtype* | No. of pCR patients | NAC group† | pCR rate (%) |
---|---|---|---|
Luminal A | 0 | 10 | 0 |
Luminal B– | 6 | 42 | 14.3 |
Luminal B+ | 8 | 24 | 33.3 |
HER2 | 6 | 22 | 27.3 |
TNBC | 13 | 49 | 26.5 |
Total | 33 | 147 | 22.4 |
pCR=pathologic complete response; CNB=core needle biopsy; NAC=neoadjuvant chemotherapy; HER2=human epidermal growth factor receptor 2; TNBC=triple-negative breast cancer.
*Classified from CNB result. luminal A (ER+ and/or PR+, HER2-, Ki-67 low); luminal B- (ER+ and/or PR+, HER2-, Ki-67 high); luminal B+ (ER+ and/or PR+, any Ki-67, HER2+); HER2 (ER-, PR-, HER2+); and TNBC (ER-, PR-, HER2-); †Five patients were equivocal HER2 result and cannot classified subtype.