Table 1.

Investigation schedule

Investigation	V0	V1	V6	V12	V18	V24	V30	V36	V42*	V48*
History	×
Clinical examination	×		×		×		×		×	×
QLMI questionnaire	A	B	B	B†	B	B†	B	B†	B	B†
Blood pressure	×		×	×	×	×	×	×	×	×
ECG	×		×		×		×		×	×
Laboratory tests	×		×		×		×		×	×
Smoking + S-cotinine	×	×	×	×	×	×	×	×	×	×
Exercise level			×	×	×	×	×	×	×	×
Nutrition + BMI	×		×	×	×	×	×	×	×	×
Alcohol status	×	×	×	×	×	×	×	×	×	×
ETT		׆×						×		×
Medication	×	×	×	×	×	×	×	×	×	×
Adverse events	×	×	×	×	×	×	×	×	×	×

^*If applicable. ^†Patient's evaluation questionnaire. ^‡ETT at the start and the end of 8 weeks of supervised exercise training.V⁰-V⁴⁸, visits at 6-month intervals; BMI, basal metabolic index.