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(a) Half-normal plot; (b) Pareto chart; (c) cube; (d), (e), and (f) 3D plots showing effect of % of acetonitrile (ACN) in mobile phase-B and pH of buffer on resolution R1; (g) effect on resolution R1 due to interaction between buffer pH and % of ACN in mobile phase-B; and (h) desirability of resolution between Impurity-VII (7) and Impurity-I (1) R1.
