Figure 5.

The microscopic appearance of the colon in different groups (n = 6 for each): (a) (negative control: healthy, vehicle, water); (b) (positive control: TNBS-induced and given only vehicle); (c) (TPGS-curcumin suspension 60 mg/kg BW); (d) (TPGS-stabilized curcumin nanosuspension 1.8 mg/kg BW); (e) (standard drug-mesalamine 180 mg/kg BW). As illustrated, there was a massive accumulation of the inflammatory cell in the untreated group (circle) and mucosal disruption in the epithelial tissue (arrow). This sign disappeared after the animals were treated, in particular after they were given the curcumin nanoparticle. Magnification 200× (1) and magnification 400× (2).