Table 3.
Pharmacokinetics of Dox after oral administration of 10 mg/kg Dox and equimolar DoxQ in rat serum (mean ± SEM, n = 4 unless otherwise stated).
| Pharmacokinetic Parameter | Dox Administered | DoxQ Administered | Cycloheximide + DoxQ Administered |
|---|---|---|---|
| Dox 1 | Dox | Dox | |
| Cmax (μg/mL) | 0.09 ± 0.01 | 0.11 ± 0.01 + | 0.07 ± 0.001 |
| Clast (μg/mL) | 0.08 ± 0.01 | 0.10 ± 0.01 | 0.07 ± 0.02 |
| Tlast (h) 2 | 4 | 4 | 4 |
| AUClast (μg * h/mL) | 0.33 ± 0.04 | 0.41 ± 0.03 + | 0.27 ± 0.005 |
| Fm (%) | NA | 10.32 ± 0.42 + | 6.81 ± 0.14 |
| F (%) | 8.57 ± 0.71 | NA | NA |
1 n = 3; 2 Median; NA = Not applicable; + p < 0.05 Dox after DoxQ versus Dox after Cycloheximide + DoxQ.