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. 2017 Jul 6;10(3):60. doi: 10.3390/ph10030060

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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BCP treatment attenuates MPTP-induced nigrostriatal dopaminergic neuronal damage. C57BL/6 mice were treated with MPTP for 5 days (30 mg/kg, i.p.). The mice were sacrificed on the 3rd day after MPTP injection after being subjected to behavioural tests. Photomicrographs of representative STR (A) sections stained with an antibody against TH. Reduced activity of TH-neurons was observed in the MPTP-treated mice, which was partially prevented by treatment with BCP. The number of TH-positive fibres in the STR (B) was expressed as the mean ± SEM of six individual experiments. *** p < 0.001, CTL vs. MPTP treatment. * p < 0.05, MPTP treatment vs. BCP + MPTP treatment. *** p < 0.001, CTL vs. AM630 + BCP + MPTP treatment.