[Table/Fig-5]:

Clinical uses of Biodentine.

Clinical applications	Related studies
Pulp capping	Laurent P et al., (39), Nowicka A et al., [55] (When Biodentine was applied directly onto pulp, it induces a reparative dentine formation due to modulation of pulp cell TGF-Beta secretion).
Pulpotomy	Villat C et al., [56] demonstrated that Biodentine should be considered as a conservative intervention in treatment of symptomatic immature teeth.
Root end filling	Pawar AM et al., 2013 [57] showed that routine endodontic therapy followed by surgical intervention with placement of biocompatible material like Biodentine for management of chronic peripapical lesions would positively affect the treatment outcome.
Dentin substitute	Koubi G et al., [58] conducted a randomized 3 years prospective study and concluded that Biodentine can be used as a dentine substitute under composite for posterior restorations.
Perforation repair (Furcal or root)	Hassan FN et al., [59] found that both ProRoot MTA and Biodentine performed equally well when used as furcation repair materials.
Root canal filling and apex closure	Han L and Okiji T 2013 [40], Elumalai D et al., 2015 [60] described that that initial healing was better in case of Biodentine when using in open apices cases however MTA showed better long term effects.