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In vitro functional selectivity of Bavarostat for HDAC6. Histone 3 (lysine 9), histone 4 (lysine 12), and α-tubulin protein acetylation levels in IPS neuroprogenitor cells after treatment with Bavarostat (10 μM), a class I HDAC inhibitor (CI-994, 10 μM), an HDAC6-selective inhibitor (Tubastatin A, 10 μM), and a mixed selectivity inhibitor (ACY1215, 5 μM), in comparison to DMSO-treated cells, indicating functional HDAC6 selectivity for Bavarostat.
