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. 2017 Sep 6;3(9):1006–1014. doi: 10.1021/acscentsci.7b00274

Figure 4.

Figure 4

Autoradiography with [18F]Bavarostat. A: Signal intensity of cerebellum relative to corpus callosum at baseline and in sagittal slices of Sprague–Dawley rat brain pretreated with 10 μM Bavarostat or Tubastatin A respectively. Blocking index = 1 – [(PTCB·PTCC–1)/(BLCB·BLCC–1)], PT = pretreated, BL = vehicle treatment, CB = cerebellum, CC = corpus callosum. ****P < 0.0001. B: Representative sagittal slices of Sprague–Dawley rat brains pretreated with vehicle, 10 μM Bavarostat, or Tubastatin A respectively.