Figure 1.
Cumulative incidences of grade III–IV acute GVHD for TAC/MTX, TAC/μMTX/MMF and TAC/MMF. TAC/MMF results in significantly greater incidence of grade III–IV acute GVHD than TAC/MTX or TAC/μMTX/MMF (a) Acute GVHD organ involvement is greater for TAC/MMF than TAC/MTX or TAC/μMTX/MMF in the gastrointestinal tract (b) but not liver (c) or skin (d) thick line—TAC/MTX, dashed line—TAC/μMTX/MMF, thin line—TAC/MMF. Abbreviations: μMTX = micro-dose MTX (7.5 mg/m2); MMF = mycophenolate mofetil; MTX = standard-dose MTX (30–40 mg/m2); TAC = tacrolimus.