Fig. 6. Diagram of the effect of ganjang compared to table salt.
When compared to table salt intake, renin and aldosterone secretion was decreased with ganjang. MR, NKAα1, NBC, NHE3, and CAII mRNA were also decreased, indicating a decrease of Na+ reabsorption. Therefore, the results from this study showed that the probability of hypertension is lower in a diet including ganjang compared to a high-salt diet, evident by down regulation of sodium transporters in the GJ group compared to the NC group. CT, Control; NC, NaCl group; GJ, ganjang group; ACE, angiotensin converting enzyme; AT1 receptor, angiotensin II type 1 receptor; MR, mineralcorticoid receptor; NKAα1, Na+/K+ ATPaseα1; NBC, Na+/HCO3- co-exchanger; NHE3, Na+/H+ exchanger 3; CAII, carbonic anhydrases II; NCX, Na+/Ca2+ exchanger.