Table 3.
Dallas, USA
|
Naples/Padova, Italy
|
|||||
---|---|---|---|---|---|---|
Prednisone | No prednisone | p Value | Prednisone | No prednisone | p Value | |
Number | 21 | 23 | 31 | 11 | ||
Age (years) | 47.3±9.3 | 51.5±10.9* | 0.18 | 52.0±13.2 | 60.0±10.5* | 0.06 |
Disease duration (months) | 83±72 | 89±92 | 0.83 | NA | NA | |
Height (m) | 1.63±0.10 | 1.65±0.07 | 0.65 | 1.64±0.08 | 1.60±0.09 | 0.23 |
Weight (kg) | 79.8±18.6 | 85.9±18.4* | 0.29 | 75.8±12.55 | 71.2±12.11* | 0.3 |
BMI (kg/m2) | 30.2±8.0 | 31.5±7.1 | 0.58 | 28.4±4.8 | 27.9±3.6 | 0.73 |
Pulmonary function | ||||||
FVC (L) | 2.43±0.71* | 2.49±0.60 | 0.78 | 3.27±1.07* | 2.51±0.48 | 0.007 |
FVC (% predicted) | 76±17* | 77±14* | 0.77 | 93±19* | 98±11* | 0.36 |
FEV1 (L) | 1.87±0.64* | 1.89±0.52 | 0.89 | 2.95±0.96* | 1.96±0.26 | 0.0001 |
FEV1 (% predicted) | 71±19* | 73±14* | 0.78 | 93±22* | 92±10* | 0.89 |
FEV1/FVC | 0.76±0.09* | 0.76±0.07 | 0.99 | 0.88±0.21* | 0.78±0.02 | 0.04 |
FEV1/FVC (% predicted) | 0.93±0.12* | 0.94±0.08 | 0.75 | 0.99±0.10* | 0.94±0.03 | 0.04 |
DLCO (mL/mm Hg/min) | 13.9±3.4* | 15.4±4.8 | 0.27 | 19.9±8.2* | 15.7±1.9 | 0.02 |
DLCO (% predicted) | 60±14* | 63±16 | 0.49 | 77±14* | 73±13 | 0.44 |
VA (L. BTPS) | 3.54±0.69 | 3.98±1.04 | 0.14 | 4.25±1.86 | 1.91±2.05 | 0.17 |
DLCO/VA | 3.92±0.70 | 3.89±0.70 | 0.89 | 3.41±1.52 | 4.61±3.37 | 0.60 |
Blood | ||||||
Creatinine (μmol/L) | 80±27 | 88±27 | 0.48 | 80±27 | 71±9 | 0.16 |
Total calcium (mmol/L) | 2.35±0.08 | 2.35±0.10 | 0.87 | 2.38±0.10 | 2.38±0.10 | 0.98 |
Phosphorus (mmol/L) | 1.03±0.23 | 1.16±0.23 | 0.09 | 1.13±0.32 | 1.16±0.26 | 0.88 |
Albumin (μmol/L) | 5.7±0.6 | 5.7±0.6 | 0.68 | 5.4±0.7 | 5.4±1.3 | 0.93 |
PTH (pmol/L) | 6.6±3.5 | 4.6±3.7 | 0.11 | 5.0±3.1 | 5.0±2.6 | 0.99 |
25-OHD (nmol/L) | 45±20 | 45±25* | 0.91 | 47±20 | 62±37* | 0.22 |
1.25-(OH)2D (pmol/L) | 104±39* | 109±47 | 0.81 | 57±23* | 104±16 | 0.09 |
24 h urine | ||||||
Volume (L/24 h) | 1.62±0.58* | 1.86±0.93* | 0.39 | 1.79±0.55* | 1.79±0.50* | 0.98 |
Calcium (mmol/24 h) | 3.44±1.77* | 3.77±2.89 | 0.68 | 8.13±4.29* | 4.72±3.64 | 0.03 |
Creatinine (mmol/24 h) | 10.88±4.39 | 11.52±3.84* | 0.66 | 10.78±4.15 | 8.72±1.57* | 0.23 |
FE-Ca (%) | 1.27±0.69* | 1.40±1.30* | 0.71 | 2.53±0.91* | 1.82±1.88* | 0.59 |
Ca/Cr ratio (mmol/mmol) | 0.34±0.17* | 0.33±0.25 | 0.85 | 0.70±0.24* | 0.51±0.50 | 0.58 |
Mean±SD. p Value indicates prednisone versus no prednisone.
Indicates p<0.05 between corresponding IT & US groups (eg, IT patient with prednisone vs US patient with prednisone). FE-Ca: Fractional excretion of calcium.
1,25-(OH)2D, 1,25-dihydroxyvitamin D; 25-OHD, 25-hydroxyvitamin-D; BMI, body mass index; BTPS, body temperature and pressure, saturated with water vapor; DLCO, diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; VA, alveolar volume; IT, Italy; US, USA.