Table 4.

Pre- and post-vitamin D repletion in US patients

	Serum							24 h Urine
US Patients	25-OHD (nmol/l)	1,25-(OH)2D (pmol/L)	Total Calcium (mmol/L)	Ionized Ca2+ (mmol/L)	PTH (pmol/L)	ACE (nKat/L)	γ-globulins (g/dL)	Calcium (mmol/24 h)	Creatinine (mmol/24 h)	Ca/Cr (mmol/mmol)	FE-Ca (%)
1	47→85	73→31	2.33→2.38	1.33→1.33	8.1→5.0	101→168	0.6→0.7	2.37→0.70	5.98→2.79	0.40→0.25	1.45→0.80
2	35→72	55→31	2.28→2.23	1.33→1.25	3.4→5.1	2412→1508*	2.2→2.0	6.99→0.62	16.07→4.28	0.44→0.15	1.81→0.61
3	57→90	107→39	2.40→2.35	1.30→1.38	11.2→7.7		0.8→0.7	3.82→2.84	21.70→22.46	0.18→0.13	0.90→0.74
4	55→95	104→65	2.35→2.43		3.1→4.1	1926→1273*	1.7→1.5	4.44→4.77	7.74→10.45	0.57→0.46	2.20→1.72
5	47→107	143→65	2.48→2.58	1.28→1.40	4.1→5.8		1.5→1.4	5.79→8.81	12.35→13.81	0.47→0.64	1.43→1.84
6	55→57	70→75	2.38→2.38		5.4→7.9	1106→905*	1.8→1.4	2.94→3.54	13.42→9.99	0.22→0.36	0.72→1.14
7	37→90	104→44	2.28→2.20	1.28→1.20	6.6→6.3	369→402	0.8→0.8	1.85→2.97	11.74→6.99	0.16→0.43	0.41→1.37
8	32→62	83→36	2.33→2.33	1.30→1.28	12.0→8.3	553→854	1.7→1.2	1.45→3.12	9.42→10.11	0.15→0.31	0.98→1.61
9	52→50	151→122	2.40→2.50	1.33→1.35	4.7→5.4	1374→1072*	2.8→2.7	2.67→1.92	7.64→6.07	0.35→0.32	0.66→0.71
10	42→100	148→49	2.38→2.55	1.38→1.50	2.4→1.3	972→838*	1.8→1.7	9.51→9.03	13.05→11.52	0.73→0.79	2.36→2.26
11	42→95	112→49	2.33→2.33	1.33→1.30	9.1→10.9	1424→1340*	2.0→1.8	0.35→2.89	13.23→17.29	0.03→0.17	0.08→0.49
12	62→70	55→39	2.43→2.40	1.40→1.35	5.3→3.9	1072→1022*	1.6→1.5	1.62→2.00	9.55→7.60	0.17→0.26	0.48→0.85
13	25→150	135→39	2.40→2.23	1.25→1.33	2.3→5.9	754→620	1.9→1.6	2.74→6.06	8.09→2.87	0.34→2.11	0.93→7.39
14	47→60	101→47	2.45→2.30	1.28→1.23	7.4→6.6	1106→1307*	2.4→2.1	1.82→0.90	7.66→7.25	0.24→0.12	0.55→0.34
15	20→62	68→68	2.40→2.78	1.30→1.48	2.9→0.3	2328→1960*	2.4→2.6	2.47→11.85	10.53→15.35	0.24→0.77	1.17→4.58
16	19→57	120→42	2.38→2.33	1.40→1.25	5.3→3.2	720→754	2.0→1.8	3.77→5.36	14.25→16.49	0.26→0.33	0.77→1.09
Mean	42→82	101→52	2.38→2.40	1.33→1.33	5.8→5.5	1106→1005	1.8→1.6	3.41→4.21	11.40→10.33	0.31→0.47	1.06→1.72
SD	12→25	31→23	0.05→0.15	0.05→0.09	3.1→2.6	687→469	0.6→0.6	2.33→3.28	3.98→5.58	0.18→0.49	0.65→1.82
p Value pre vs post	0.0001	<0.0001	0.58	0.67	0.54	0.09	0.002	0.34	0.32	0.18	0.17

Mean±SD, Pre → Post-repletion.

^*Indicates patients with elevated baseline angiotensin converting enzyme (ACE). In this subgroup, ACE levels dropped from 1524±553 pre-repletion to 1240±352 nKat/L (p=0.04) postrepletion.

1,25-(OH)₂D, 1,25-dihydroxyvitamin D; 25-OHD, 25-hydroxyvitamin-D; Ca/Cr, calcium to creatinine ratio; FE-Ca, fractional excretion of calcium; PTH, parathyroid hormone.