Performance of the state of art. (a) Visual samples of the vessel segmentation obtained applying Barbalata and Mattos6 algorithm to patches with hypertrophic vessels (first row), healthy tissue (second row), and IPCL-like vessels (third row). From left to right, original patch, vessel mask, and vessel mask superimposed on the original patch. (b) Normalized confusion matrix obtained applying Barbalata and Mattos6 algorithm to our dataset. Colorbar indicates the number of patches. The total number of patches (no. of patches) is reported.