Figure 7. Decreased T‐current densities and bursting in the subiculum of Ca_V3.1 KO mice.

A, representative averaged original traces of subicular T‐currents from WT mice (black line), Ca_V3.1 KO mice (red line) and Ca_V3.2 KO mice (green line). B, bar graphs represent averaged current amplitudes after −110 mV prepulse during the steady‐state inactivation protocols in three cohorts as depicted in panel A of this figure. Note that average current amplitudes are significantly decreased only in Ca_V3.1 KO mice when compared to WT mice. C, original traces from representative of the four spike firing patterns identified in the WT mouse subiculum as a response to a 500‐ms depolarizing current injection. D, pie charts representing the percentages of different firing patterns of subicular neurons in C57BL/6J, Ca_V3.1 KO and Ca_V3.2 KO mice: RS, regular‐spiking; FS, fast‐spiking; WB, weak bursting; SB, strong bursting; total n = 222 neurons. Note the smaller portion of burst firing neurons and larger portion of regular spiking neurons in Ca_V3.1 KO mice when compared to C57BL/6J WT mice.