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The AMPAkine CX546 produces additional pain relief after morphine administration in a paw incision (PI) model of acute postoperative pain. A. PI induces mechanical allodynia associated with acute pain. Unpaired Student’s t test. n=8, **** p<0.0001. B. The combination of CX546 and morphine provides greater relief of mechanical allodynia than morphine alone in PI-treated rats. Unpaired Student’s t test. n=8-11, * p=0.0479.
