TABLE 1.

Search Terms and Inclusion/Exclusion Criteria by Topic Area

Topic Area	Search Terms	Search Dates	Other Search Criteria
Full mutation phenotype	Fragile X syndrome, fragile X–associated disorders, fragile X premutation, fragile X carrier, fragile X–associated tremor/ataxia syndrome, or fragile X–associated primary ovarian insufficiency and phenotype, clinical presentation, clinical description, neurocognitive, cognitive, behavior, social-emotional, or language, communication	2008–2014	English language Human United States only
Developmental trajectories across the life span	Fragile X syndrome or fragile X and lifespan, developmental, longitudinal, adolescent, adult, services, or transition to adulthood	1991–2014	English language Human
Available interventions and treatments	Fragile X syndrome or fragile X and treatment, intervention, pharmacological, educational, behavioral, medication, or clinical trial	1991–2014	English language Human
Impact on family	Fragile X syndrome or fragile X and family adaptation, family impact, family outcomes, burden, or cost of care	1991–2014	English language Human United States only