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. Author manuscript; available in PMC: 2018 Sep 27.
Published in final edited form as: Neuron. 2017 Sep 27;96(1):115–129.e5. doi: 10.1016/j.neuron.2017.09.003

Figure 8. Aged ApoE4-TR Mice Exhibit Elevated Early Endosomal Marker. See also Figure S10.

Figure 8

Brain slices from apoE3-TR and apoE4-TR mice at 22 months of age were prepared, and the early endosomes were examined by immunohistochemical staining for Rab5. The Rab5 expression pattern in the cortex and amygdala is shown (A). Scale bar, 100 μm. (B and C) The immunoreactivity of Rab5 staining in the cortex and amygdala from apoE3-TR and apoE4-TR mice was quantified using Aperio ImageScope (n=6 mice/genotype, mixed gender). Data are expressed as mean ± SEM relative to apoE3-TR mice. Two-tailed student’s t test was used for statistical analysis. *p<0.05.